the allergy relief center - your best resource for allergy relief products.
a formula of natural enzymes, in precisely measured dose, gives effective relief for sufferers of sinus problems, of problems clearing the ears in flight and in scuba diving, inflammation from injury, and in many other problems relating to swelling and inflammation.
clear�ease is made of natural fruit enzymes, papain and bromelain. papain comes from the latex of green papaya fruit. bromelain comes from pineapple stems and fruits. they are called proteolytic enzymes because they break up biological products like thick mucus.
proteolytic enzymes are involved with repair and healing in the body. they have anti-inflammatory action. in the 50's, dozens of clinical trials that showed that these enzymes yielded clear positive results, when they were administered via buccal route, i.e. dissolved slowly between the cheek and gums. later, however, it was often administered orally, because this was thought to be more convenient. in fact, digestion in the stomach reduced the effectiveness of these enzymes, and they failed to become a popular treatment - until recently.
papain and bromelain are used for:
there have been hundreds of articles on such enzymatic treatments. enzymes were found to be especially valuable for the anti-inflammatory effects after injury. there are several modes of action of proteases as an anti-inflammatory agent. there is a reduction in the viscosity of extracellular fluid. there is prevention of excess clot formation. there is an aid to phagocytic function. there is a decrease in anti-inflammatory products.
unfortunately, it wasn't until recently that it was recognized that only a small amount of the bromelain/ papain enzyme was absorbed from the stomach. a second problem has been that the products used for study often were measured in grams of weight. this is meaningless; what is needed is a measure of the enzymatic activity. a pound of yeast won't make bread if the yeast is dead.
in order for the protease products to exert systemic effects, they must be active when they reach the inflamed sites. unfortunately they are inactivated by stomach and intestine. protease activity via oral route is only between 1 to 40% absorbed. fortunately, however, the activity tends to concentrate at inflamed sites.
studies have shown anti-inflammatory activity in sports injuries, especially boxing and contact sports. but they must be taken early - preferably before the contest. blonstein reported on boxers. he administered the protease via buccal route. among boxers there was less bruising. cuts took 1/2 the time to heal. healing was much faster. results were better when the protease was started immediately before or after injury.
sprains, concussions, and pulled muscles all did better on proteases. several articles indicated superior healing post operatively. in one standardized surgical procedure, there was reduction of inflammation, pain, edema and swelling in most subjects.
cohen and goldman studies bromelain's effects on joint status in cases of rheumatoid arthritis. 72% showed reduction of joint swelling. studies showed it to be helpful in bursitis, tendinitis, and sciatica.
the reduction of pain and swelling is somewhat similar in protease and non steroidal anti-inflammatory products such as naprosyn. a significant difference is that protease enzymes accelerate healing.
various studies have shown that combinations of enzymes usually work better than a single one. this is because, for example, papain and bromelain have slightly different actions so that in combination they are synergistic.
studies have showed the effects of these enzymes on thinning thick mucus.
i have used the anti-inflammatory properties of the enzymes for blocked eustachian tube. reduction of inflammation, thinning the mucus, reducing nasal sinus inflammation has been so effective that i have dozens of pilots and scuba divers on the enzyme.
i have used the enzymes for swelling about the nerve, as in bell's palsy. here the 7th nerve swells within the bony canal in the ear and this cuts off nourishment to that nerve. by reducing swelling we can save the nerve.
one of the more dramatic application has been in swelling of the salilvary glands. these are the parotid gland, in back of the cheek where you get mumps swelling and the submaxillary gland, under the lower jaw. this is called sialidinitis.(inflammation of the salivary gland). the combination of anti-inflammatory, thinning the secretions, reducing edema, and helping the antibiotic get to the affected area has made this a standard treatment for my patients when the saliva glands are affected. helps, even if there is a stone blocking the duct. occasionally this would help the stone eject.
temperomandibular joint disorder is very common. often the jaw opens to the side and the patient may clench his jaw or grind his teeth. these enzymes reduce swelling within the jaw joint. with the reduction of swelling, normal movement can now occur which also speeds healing. for my patients i have them take the enzyme at the beginning of the symptoms.
for swollen uvula the enzymes can be very helpful. you can get reduction of painful swelling right away.
hoarseness and laryngitis involve swelling and inflammation. as soon as the vocal cords swell, the voice is altered. for singers and speakers the smallest change can dramatically affect the voice. here the anti-inflammatory action of the papain/bromelain combination is extremely useful.
sinus pain is potentiated by swelling of the sinus membranes or pressure on the membranes. the worst swelling is a vacuum sinus pain. here the flyer has come down from an altitude of say 30,000 feet. on descent the sinus cavity/cavities blocked, so now the pressure on the outside is much greater than the pressure on the inside of the sinus. it is like having a 4 pound weight on the cornea of the eye. the pain is much greater than pain from a bad infection. the enzymes reduce this readily.
in cystic fibrosis the mucus is very thick. a protease called dornase from genentec is used to thin the mucus. the fruit enzymes may help with a somewhat related mechanism.
painful nasal membranes occur with dry irritated enflamed membranes. the anti-inflammatory action of the enzymes is useful here.
with clear�ease there is a standardized enzymatic activity. this is carefully calibrate. the papain/bromelain combination has been found to be more effective than each alone because each has a slightly different mode of action.
most important, this tablet is designed for buccal use. it can be used without regards to meals. there is no sugar in the tablet so that irritation from sugar is eliminated. the tablet melts rapidly and there is no "waste" from stomach acid inactivation.
blonsteinjl. control of swellng in boxing injuries. practitioner 1969;203-206 buccal or sublingual delivery. use of buccal papaya resulted in less swelling, less hematoma.
blonsteinjl. the use of buccal varidase in boxing injuries. practitioner 1967;198:547 cuts took 1/2 time to heal.
cohen a, goldman j. bromelains therapy in rheumatoid arthritis. pennsylvania med j 1964;67:27&endash;30. antiinflammatory properties of bromelain for arthritis
cirelli mg bromelain use in arthritis . clinical medicine with bromelain arthritis, muscle and back pain was improved
craig rp. the quantitative evaluation of the use of oral proteolytic enzymes in the treatment of sprained ankles. injury 1975; 6:313 ankles healed faster and with less pain on enzymes.
dietrich re. oral proteolytic enzymes in the treatment of athletic injuries. penn. med j. 1965;68:35 use of protease enzymes reduced injury time for acute sprains, contousions and strains.
felton g.e. does kinin released by pineapple stem of bromelain stimulate production of prostagalandin like compounds? hawaii journal of medicine 36(2):39 1977 bromelain use reduces coughs and bronchitis and relieves sinus symptoms.
gaby ar. the story of bromelain. nutr healing may 1995:3,4,11. use for sinus pain, blocked bronchial passages, asthma and allergy.
grossan, m. help your patients have a healthy vacation. consultant magazine.april 1982, 22:4 pp256-258 papaya enzyme can be used to insure a trouble free dive trip.
grossan m. care of the scuba diver. osteopathic annals october 1976 the use of papaya enzyme taken via buccal route for blocked ears.
grossan m. enhancing the mucociliary system. advance for respiratory care practitioners. april 17, 1995. 8:12-13 for chest congestion due to thick mucus, the proteolytic enzyme can aid significantly.
grossan m. office measurement of nasal mucociliary clearance. english: otolaryngology 1994, vol 2 chapter 7 because the mucus is thinned by the enzyjes, nasal and sinus mucociliary movement is enhanced.
holt ht. carica papaya as ancillary therapy for athletic injuries. curr ther res 1969;11:621 papain tablets showed a significantly better than expected recovery in sprains, strains, contusions. best results when started immediately after injury.
howatt rcl. the effect of bromelain therapy on episiotomy wounds. j. ostet, gynaecol. br. common. 1972;79:951 reduction of post operative pain and swelling occured in 1,788 patients.
ito c, yamaguchi k. anti -inflammatory actions of proteases, bromelain, trypsin, and their mixed preparation. nippon yakurigaku zasshi 1979 april 20; 75(3).227 - 37 mixed preparations showed anti-inflammatory actions indicating synergism. inhibition against edema. inhibition against histamine induced vascular permeability. anti-inflammatory action seems best against acute exudative inflammation.
kelly gs. bromelain: a literature review and discussion of its therapeutic applications. alt med rev 1996;1:243&endash;57 use for sinusitis, joint and muscle swelling and to aid in effectiveness of antibiotics.
lotz-winter h on the pharmacologiy of bromelain. planta medica.56 (3):249 1970 bromelain lowers inflammation quickly.
majima y, inagaki m. the effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. archives of oto-rhino-layngology 1988 244:335-359
martin gj. bromelain pineapple proteases with anti-edema activivity. exper med surg 1962;20:228-48. reduction of extra cellular edema.
masson m. bromelain in the treatment of blunt injuries to the musculoskeletal system. fortschr med 1995;113(19):303&endash;6. treatment for injuries to muscles and joints
metzig c. bromelain proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation. in vivo, 13(1):7-12 1999 jan-feb proteases are shown to have antithrombolytic activity and is helpful for thrombosis and inflammation.
ryan re. evaluation of bromelains in the treatment of acute sinusitis. headache 1967;7:13-7 when used for sinus pain, enzymes were effective in relieving sinus pain.
schafer a, adelman b. plasma inhibition of platelet function and of arachidonic acid metabolism. j clin invest 1985;75:456&endash;61. action on platelet aggregation is one of the antiinflammatory actions of bromelain/papain
seltzer ap. minimizing post-operative edema and ecchymosis by the use of an oral enzyme preparaton bromelain. eent monthly 1962;41:813-7 reduction of hematoma, swelling and pain post op.
seltzerap. adjunctive use of bromelains in sinusitis. eent monthly 1967;46:1281-8. less pain and faster recovery when enzymes were used combined with other sinusitis treatment
taub sj. the use of ananase in sinusitis-a study of 60 patients. eent monthly 1966;45: 96-8 less post operative swelling in patients given enzymes pre op.
taussig,sj. the mechanism of the physiological action of bromelain . med hypoth 1980;6:99-104 bromelain acts to reduce inflammation.
taussig sj. bromelain: a proteolytic enzyme and its clinical application. hiroshima j med sci, 24:185 1975 sep use of bromelain in postoperative care, wounds and thromaboplebitis
tsomides j. controlled evaluation of oral chymotrypsin-trypsin treatment of injuries to the head and face. clin. med 1969;76:40 protease administration was effective in reducing signs of swellng and bruising in traumatic facial injuries
walker ja. attenuation of contraction-induced skeletal muscle injury by bromelain. med sci sports exerc, 24(1):20-5 1992 jan experiments showed bromelain reduced muscle injury.
white rr bioavailability of 125i bromelain after oral administration to rats. biopharm drug dispos, 9(4):397-403 1988 jul-aug there is less than 40 percent of product available from oral administration.